Phosphatidylinositol 3'-kinase and p70s6k are required for insulin but not bisperoxovanadium 1,10-phenanthroline (bpV(phen)) inhibition of insulin-like growth factor binding protein gene expression. Evidence for MEK-independent activation of mitogen-activated protein kinase by bpV(phen). [electronic resource]
- The Journal of biological chemistry Jan 1997
- 138-45 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
0021-9258
10.1074/jbc.272.1.138 doi
Androstadienes--pharmacology Animals Calcium-Calmodulin-Dependent Protein Kinases--metabolism Cells, Cultured Dexamethasone--pharmacology Enzyme Activation Enzyme Inhibitors--pharmacology Glucagon--pharmacology Insulin--pharmacology Insulin-Like Growth Factor Binding Protein 1--genetics Insulin-Like Growth Factor Binding Protein 4--genetics Liver--metabolism MAP Kinase Kinase 1 Mitogen-Activated Protein Kinase 1 Mitogen-Activated Protein Kinase 3 Mitogen-Activated Protein Kinase Kinases Mitogen-Activated Protein Kinases Organometallic Compounds--pharmacology Phenanthrolines--pharmacology Phosphatidylinositol 3-Kinases Phosphotransferases (Alcohol Group Acceptor)--physiology Polyenes--pharmacology Protein Serine-Threonine Kinases--antagonists & inhibitors Protein Tyrosine Phosphatases--antagonists & inhibitors Protein-Tyrosine Kinases--antagonists & inhibitors RNA, Messenger--genetics Rats Rats, Sprague-Dawley Ribosomal Protein S6 Kinases Signal Transduction Sirolimus Wortmannin