TY  - GEN
AU  - Tsiang,M
AU  - Paborsky,L R
AU  - Li,W X
AU  - Jain,A K
AU  - Mao,C T
AU  - Dunn,K E
AU  - Lee,D W
AU  - Matsumura,S Y
AU  - Matteucci,M D
AU  - Coutré,S E
AU  - Leung,L L
AU  - Gibbs,C S
TI  - Protein engineering thrombin for optimal specificity and potency of anticoagulant activity in vivo
SN  - 0006-2960
PY  - 1997///0130
KW  - Animals
KW  - Anticoagulants
KW  - pharmacology
KW  - Blood Coagulation
KW  - drug effects
KW  - Drug Evaluation, Preclinical
KW  - Fibrinogen
KW  - metabolism
KW  - Half-Life
KW  - Humans
KW  - Kinetics
KW  - Macaca fascicularis
KW  - Models, Molecular
KW  - Mutagenesis, Site-Directed
KW  - Platelet Activation
KW  - Protein C
KW  - Protein Conformation
KW  - Protein Engineering
KW  - Substrate Specificity
KW  - Thrombin
KW  - genetics
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1021/bi9616108
ER  -