Tsiang, M <br/><br/>
Protein engineering thrombin for optimal specificity and potency of anticoagulant activity in vivo.  [electronic resource] 

 -  Biochemistry  Dec 1996 
 - 16449-57 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>0006-2960 
<br/><br/><label>Standard No.: </label>10.1021/bi9616108  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Animals<br/>Anticoagulants--pharmacology<br/>Blood Coagulation--drug effects<br/>Drug Evaluation, Preclinical<br/>Fibrinogen--metabolism<br/>Half-Life<br/>Humans<br/>Kinetics<br/>Macaca fascicularis<br/>Models, Molecular<br/>Mutagenesis, Site-Directed<br/>Platelet Activation--drug effects<br/>Protein C--metabolism<br/>Protein Conformation<br/>Protein Engineering<br/>Substrate Specificity<br/>Thrombin--genetics