TY - GEN AU - Ling,Z AU - Pipeleers,D G TI - Prolonged exposure of human beta cells to elevated glucose levels results in sustained cellular activation leading to a loss of glucose regulation SN - 0021-9738 PY - 1997///0130 KW - Analysis of Variance KW - Cells, Cultured KW - DNA KW - analysis KW - Glucose KW - pharmacology KW - Humans KW - Immunohistochemistry KW - Insulin KW - metabolism KW - Insulin Secretion KW - Islets of Langerhans KW - drug effects KW - Proteins KW - Tyrosine N1 - Publication Type: Journal Article; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1172/JCI119108 ER -