TY  - GEN
AU  - van der Put,N M
AU  - van den Heuvel,L P
AU  - Steegers-Theunissen,R P
AU  - Trijbels,F J
AU  - Eskes,T K
AU  - Mariman,E C
AU  - den Heyer,M
AU  - Blom,H J
TI  - Decreased methylene tetrahydrofolate reductase activity due to the 677C-->T mutation in families with spina bifida offspring
SN  - 0946-2716
PY  - 1997///0305
KW  - 5,10-Methylenetetrahydrofolate Reductase (FADH2)
KW  - Adult
KW  - Aged
KW  - Child
KW  - Cysteine
KW  - blood
KW  - Female
KW  - Folic Acid
KW  - Genetic Linkage
KW  - Genotype
KW  - Homocysteine
KW  - Homozygote
KW  - Humans
KW  - Lod Score
KW  - Lymphocytes
KW  - enzymology
KW  - Male
KW  - Methylenetetrahydrofolate Reductase (NADPH2)
KW  - Middle Aged
KW  - Netherlands
KW  - Oxidoreductases
KW  - deficiency
KW  - Point Mutation
KW  - genetics
KW  - Risk Factors
KW  - Spinal Dysraphism
KW  - epidemiology
KW  - Vitamin B 12
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1007/s001090050073
ER  -