Dunn, W J <br/><br/>
Solution of the conformation and alignment tensors for the binding of trimethoprim and its analogs to dihydrofolate reductase: 3D-quantitative structure-activity relationship study using molecular shape analysis, 3-way partial least-squares regression, and 3-way factor analysis.  [electronic resource] 

 -  Journal of medicinal chemistry  Nov 1996 
 - 4825-32 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. 
<br/><br/><label>ISSN: </label>0022-2623 
<br/><br/><label>Standard No.: </label>10.1021/jm960491r  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Chemical Phenomena<br/>Chemistry<br/>Crystallography, X-Ray<br/>Drug Design<br/>Enzyme Inhibitors--chemistry<br/>Escherichia coli--enzymology<br/>Folic Acid Antagonists--chemistry<br/>Molecular Conformation<br/>Molecular Structure<br/>Structure-Activity Relationship<br/>Tetrahydrofolate Dehydrogenase--chemistry<br/>Trimethoprim--analogs & derivatives