Regulation of interleukin-2 transcription by inducible stable expression of dominant negative and dominant active mitogen-activated protein kinase kinase kinase in jurkat T cells. Evidence for the importance of Ras in a pathway that is controlled by dual receptor stimulation. [electronic resource]
- The Journal of biological chemistry Nov 1996
- 27366-73 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
0021-9258
10.1074/jbc.271.44.27366 doi
Base Sequence CD28 Antigens--physiology Calcium-Calmodulin-Dependent Protein Kinases--metabolism DNA Primers Enzyme Activation Gene Expression Regulation, Enzymologic Gene Expression Regulation, Neoplastic Humans Interleukin-2--biosynthesis JNK Mitogen-Activated Protein Kinases Jurkat Cells Kinetics MAP Kinase Kinase 1 MAP Kinase Kinase Kinases Mitogen-Activated Protein Kinase Kinases Mitogen-Activated Protein Kinases Polymerase Chain Reaction Promoter Regions, Genetic Protein Serine-Threonine Kinases--metabolism Protein-Tyrosine Kinases--metabolism RNA, Messenger--biosynthesis Receptor-CD3 Complex, Antigen, T-Cell--physiology T-Lymphocytes Transcription, Genetic Transcriptional Activation ras Proteins--metabolism