TY  - GEN
AU  - Lave,T
AU  - Dupin,S
AU  - Schmitt,M
AU  - Kapps,M
AU  - Meyer,J
AU  - Morgenroth,B
AU  - Chou,R C
AU  - Jaeck,D
AU  - Coassolo,P
TI  - Interspecies scaling of tolcapone, a new inhibitor of catechol-O-methyltransferase (COMT). Use of in vitro data from hepatocytes to predict metabolic clearance in animals and humans
SN  - 0049-8254
PY  - 1997///0311
KW  - Animals
KW  - Benzophenones
KW  - blood
KW  - Catechol O-Methyltransferase Inhibitors
KW  - Cells, Cultured
KW  - Dogs
KW  - Enzyme Inhibitors
KW  - pharmacokinetics
KW  - Humans
KW  - Liver
KW  - cytology
KW  - Male
KW  - Metabolic Clearance Rate
KW  - Models, Biological
KW  - Nitrophenols
KW  - Pharmacokinetics
KW  - Predictive Value of Tests
KW  - Rabbits
KW  - Rats
KW  - Rats, Inbred Strains
KW  - Species Specificity
KW  - Time Factors
KW  - Tolcapone
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.3109/00498259609046754
ER  -