Lave, T <br/><br/>
Interspecies scaling of tolcapone, a new inhibitor of catechol-O-methyltransferase (COMT). Use of in vitro data from hepatocytes to predict metabolic clearance in animals and humans.  [electronic resource] 

 -  Xenobiotica; the fate of foreign compounds in biological systems  Aug 1996 
 - 839-51 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>0049-8254 
<br/><br/><label>Standard No.: </label>10.3109/00498259609046754  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Animals<br/>Benzophenones--blood<br/>Catechol O-Methyltransferase Inhibitors<br/>Cells, Cultured<br/>Dogs<br/>Enzyme Inhibitors--pharmacokinetics<br/>Humans<br/>Liver--cytology<br/>Male<br/>Metabolic Clearance Rate<br/>Models, Biological<br/>Nitrophenols<br/>Pharmacokinetics<br/>Predictive Value of Tests<br/>Rabbits<br/>Rats<br/>Rats, Inbred Strains<br/>Species Specificity<br/>Time Factors<br/>Tolcapone