TY - GEN AU - McGee,T P AU - Cheng,H H AU - Kumagai,H AU - Omura,S AU - Simoni,R D TI - Degradation of 3-hydroxy-3-methylglutaryl-CoA reductase in endoplasmic reticulum membranes is accelerated as a result of increased susceptibility to proteolysis SN - 0021-9258 PY - 1996///1119 KW - Acetylcysteine KW - analogs & derivatives KW - Animals KW - CHO Cells KW - Cell Fractionation KW - Cell Line, Transformed KW - Cricetinae KW - Cysteine Endopeptidases KW - metabolism KW - Cysteine Proteinase Inhibitors KW - pharmacology KW - Detergents KW - Endopeptidases KW - Endoplasmic Reticulum KW - enzymology KW - Enzyme Inhibitors KW - Enzyme Stability KW - Hydroxycholesterols KW - Hydroxymethylglutaryl CoA Reductases KW - Intracellular Membranes KW - Kidney KW - Kinetics KW - Mevalonic Acid KW - Multienzyme Complexes KW - Proteasome Endopeptidase Complex KW - Thermodynamics N1 - Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S UR - https://doi.org/10.1074/jbc.271.41.25630 ER -