Breton, R <br/><br/>
The structure of a complex of human 17beta-hydroxysteroid dehydrogenase with estradiol and NADP+ identifies two principal targets for the design of inhibitors.  [electronic resource] 

 -  Structure (London, England : 1993)  Aug 1996 
 - 905-15 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>0969-2126 
<br/><br/><label>Standard No.: </label>10.1016/s0969-2126(96)00098-6  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Amino Acid Sequence<br/>Antineoplastic Agents--chemistry<br/>Binding Sites--drug effects<br/>Catalysis<br/>Crystallography, X-Ray<br/>Drug Design<br/>Enzyme Inhibitors--chemistry<br/>Estradiol--chemistry<br/>Estradiol Dehydrogenases--antagonists & inhibitors<br/>Estrone--metabolism<br/>Female<br/>Humans<br/>Macromolecular Substances<br/>Models, Molecular<br/>Molecular Conformation<br/>Molecular Sequence Data<br/>NADP--chemistry<br/>Oxidation-Reduction<br/>Oxygen--chemistry<br/>Placenta--enzymology<br/>Protein Binding--drug effects<br/>Protein Conformation<br/>Recombinant Proteins--chemistry<br/>Serine--chemistry<br/>Substrate Specificity<br/>Temperature<br/>Tyrosine--chemistry