TY  - GEN
AU  - Lekehal,M
AU  - Pessayre,D
AU  - Lereau,J M
AU  - Moulis,C
AU  - Fouraste,I
AU  - Fau,D
TI  - Hepatotoxicity of the herbal medicine germander: metabolic activation of its furano diterpenoids by cytochrome P450 3A Depletes cytoskeleton-associated protein thiols and forms plasma membrane blebs in rat hepatocytes
SN  - 0270-9139
PY  - 1996///0910
KW  - Acetylcysteine
KW  - pharmacology
KW  - Animals
KW  - Biotransformation
KW  - Cell Membrane
KW  - drug effects
KW  - Cysteine
KW  - Cystine
KW  - Cytochrome P-450 CYP2E1
KW  - Cytochrome P-450 Enzyme System
KW  - metabolism
KW  - Cytoskeleton
KW  - Dexamethasone
KW  - Diterpenes
KW  - Diterpenes, Clerodane
KW  - Female
KW  - Glutathione
KW  - Liver
KW  - Male
KW  - Mixed Function Oxygenases
KW  - Phytotherapy
KW  - Plant Extracts
KW  - Rats
KW  - Rats, Sprague-Dawley
KW  - Spiro Compounds
KW  - Troleandomycin
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1002/hep.510240134
ER  -