Lekehal, M <br/><br/>
Hepatotoxicity of the herbal medicine germander: metabolic activation of its furano diterpenoids by cytochrome P450 3A Depletes cytoskeleton-associated protein thiols and forms plasma membrane blebs in rat hepatocytes.  [electronic resource] 

 -  Hepatology (Baltimore, Md.)  Jul 1996 
 - 212-8 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>0270-9139 
<br/><br/><label>Standard No.: </label>10.1002/hep.510240134  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Acetylcysteine--pharmacology<br/>Animals<br/>Biotransformation<br/>Cell Membrane--drug effects<br/>Cysteine--pharmacology<br/>Cystine--pharmacology<br/>Cytochrome P-450 CYP2E1<br/>Cytochrome P-450 Enzyme System--metabolism<br/>Cytoskeleton--drug effects<br/>Dexamethasone--pharmacology<br/>Diterpenes--metabolism<br/>Diterpenes, Clerodane<br/>Female<br/>Glutathione--metabolism<br/>Liver--drug effects<br/>Male<br/>Mixed Function Oxygenases--metabolism<br/>Phytotherapy<br/>Plant Extracts--metabolism<br/>Rats<br/>Rats, Sprague-Dawley<br/>Spiro Compounds--metabolism<br/>Troleandomycin--pharmacology