TY  - GEN
AU  - Leftheris,K
AU  - Kline,T
AU  - Vite,G D
AU  - Cho,Y H
AU  - Bhide,R S
AU  - Patel,D V
AU  - Patel,M M
AU  - Schmidt,R J
AU  - Weller,H N
AU  - Andahazy,M L
AU  - Carboni,J M
AU  - Gullo-Brown,J L
AU  - Lee,F Y
AU  - Ricca,C
AU  - Rose,W C
AU  - Yan,N
AU  - Barbacid,M
AU  - Hunt,J T
AU  - Meyers,C A
AU  - Seizinger,B R
AU  - Zahler,R
AU  - Manne,V
TI  - Development of highly potent inhibitors of Ras farnesyltransferase possessing cellular and in vivo activity
SN  - 0022-2623
PY  - 1996///0301
KW  - 3T3 Cells
KW  - Alkyl and Aryl Transferases
KW  - Animals
KW  - Antineoplastic Agents
KW  - chemical synthesis
KW  - Brain
KW  - enzymology
KW  - Cell Division
KW  - drug effects
KW  - Cell Line, Transformed
KW  - Cell Transformation, Neoplastic
KW  - Drug Design
KW  - Enzyme Inhibitors
KW  - Genes, ras
KW  - genetics
KW  - Glutamates
KW  - Isoquinolines
KW  - Methionine
KW  - analogs & derivatives
KW  - Mice
KW  - Mice, Nude
KW  - Molecular Structure
KW  - Neoplasm Transplantation
KW  - Oncogene Protein p21(ras)
KW  - metabolism
KW  - Protein Prenylation
KW  - Rats
KW  - Swine
KW  - Tetrahydroisoquinolines
KW  - Transfection
KW  - Transferases
KW  - antagonists & inhibitors
KW  - Tumor Cells, Cultured
KW  - Valine
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1021/jm950642a
ER  -