Leftheris, K <br/><br/>
Development of highly potent inhibitors of Ras farnesyltransferase possessing cellular and in vivo activity.  [electronic resource] 

 -  Journal of medicinal chemistry  Jan 1996 
 - 224-36 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>0022-2623 
<br/><br/><label>Standard No.: </label>10.1021/jm950642a  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>3T3 Cells<br/>Alkyl and Aryl Transferases<br/>Animals<br/>Antineoplastic Agents--chemical synthesis<br/>Brain--enzymology<br/>Cell Division--drug effects<br/>Cell Line, Transformed<br/>Cell Transformation, Neoplastic--drug effects<br/>Drug Design<br/>Enzyme Inhibitors--chemical synthesis<br/>Genes, ras--genetics<br/>Glutamates--chemical synthesis<br/>Isoquinolines--chemical synthesis<br/>Methionine--analogs & derivatives<br/>Mice<br/>Mice, Nude<br/>Molecular Structure<br/>Neoplasm Transplantation<br/>Oncogene Protein p21(ras)--metabolism<br/>Protein Prenylation--drug effects<br/>Rats<br/>Swine<br/>Tetrahydroisoquinolines<br/>Transfection<br/>Transferases--antagonists & inhibitors<br/>Tumor Cells, Cultured<br/>Valine--analogs & derivatives