Breaching the conformational integrity of the catalytic triad of the serine protease plasmin: localized disruption of a side chain of His-603 strongly inhibits the amidolytic activity of human plasmin. [electronic resource]
- Proceedings of the National Academy of Sciences of the United States of America Jun 1993
- 5374-7 p. digital
Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
0027-8424
10.1073/pnas.90.11.5374 doi
Amino Acid Sequence Animals Baculoviridae--genetics Base Sequence Cell Line Chromatography, Affinity Fibrinolysin--chemistry Histidine Humans Imidazoles--pharmacology Isoflurophate--pharmacology Kinetics Molecular Sequence Data Moths Mutagenesis, Site-Directed Oligodeoxyribonucleotides Proline Protein Conformation Recombinant Proteins--chemistry Transfection