TY  - GEN
AU  - Monge,A
AU  - Aldana,I
AU  - Losa,M J
AU  - Font,M
AU  - Castiella,E
AU  - Frechilla,D
AU  - Cenarruzabeitia,E
AU  - Martinez de Irujo,J J
AU  - Lopez-Unzu,J
AU  - Alberdi,E
TI  - A novel class of cardiotonic agents: synthesis and biological evaluation of pyridazino[4,5-b]indoles with cyclic AMP phosphodiesterases inhibiting properties
SN  - 0022-3549
PY  - 1993///0928
KW  - 3',5'-Cyclic-AMP Phosphodiesterases
KW  - antagonists & inhibitors
KW  - Animals
KW  - Aorta, Thoracic
KW  - drug effects
KW  - Blood Platelets
KW  - Cardiotonic Agents
KW  - chemical synthesis
KW  - Dogs
KW  - Female
KW  - Guinea Pigs
KW  - Heart
KW  - Humans
KW  - In Vitro Techniques
KW  - Indoles
KW  - Isoenzymes
KW  - Male
KW  - Myocardium
KW  - enzymology
KW  - Phosphodiesterase Inhibitors
KW  - pharmacology
KW  - Platelet Aggregation
KW  - Platelet Aggregation Inhibitors
KW  - Pyridazines
KW  - Rats
KW  - Rats, Wistar
KW  - Structure-Activity Relationship
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1002/jps.2600820519
ER  -