Kuo, S C

Synthesis and cytotoxicity of 1,6,7,8-substituted 2-(4'-substituted phenyl)-4-quinolones and related compounds: identification as antimitotic agents interacting with tubulin. [electronic resource] - Journal of medicinal chemistry Apr 1993 - 1146-56 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

0022-2623

10.1021/jm00061a005 doi


Animals
Antineoplastic Agents--chemical synthesis
Humans
Intestinal Neoplasms--drug therapy
Leukemia L1210--drug therapy
Leukemia P388--drug therapy
Lung Neoplasms--drug therapy
Melanoma--drug therapy
Mice
Molecular Structure
Nasopharyngeal Neoplasms--drug therapy
Quinolines--chemical synthesis
Quinolones--chemical synthesis
Software
Structure-Activity Relationship
Tubulin--metabolism
Tubulin Modulators
Tumor Cells, Cultured