Jaw, S

Interaction of caffeine with acetaminophen. 1. Correlation of the effect of caffeine on acetaminophen hepatotoxicity and acetaminophen bioactivation following treatment of mice with various cytochrome P450 inducing agents. [electronic resource] - Biochemical pharmacology Aug 1993 - 493-501 p. digital

Publication Type: Comparative Study; Journal Article

0006-2952

10.1016/0006-2952(93)90526-3 doi


Acetaminophen--toxicity
Acetone
Aminopyrine N-Demethylase--biosynthesis
Animals
Aryl Hydrocarbon Hydroxylases
Benzoflavones
Benzoquinones--metabolism
Biotransformation--drug effects
Caffeine--pharmacology
Chemical and Drug Induced Liver Injury
Cytochrome P-450 CYP3A
Cytochrome P-450 Enzyme System--biosynthesis
Dexamethasone
Drug Interactions
Enzyme Activation
Female
Imines--metabolism
Isoenzymes--metabolism
Kinetics
Liver Diseases--enzymology
Mice
Microsomes, Liver--drug effects
Oxidoreductases, N-Demethylating--biosynthesis
Phenobarbital
beta-Naphthoflavone