Determination of tissue specificity of the enhancer by combinatorial operation of tissue-enriched transcription factors. Both HNF-4 and C/EBP beta are required for liver-specific activity of the ornithine transcarbamylase enhancer. [electronic resource]
- The Journal of biological chemistry Jan 1994
- 1323-31 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
0021-9258
Animals Base Sequence Basic Helix-Loop-Helix Leucine Zipper Transcription Factors Binding Sites CCAAT-Enhancer-Binding Proteins CHO Cells Cricetinae DNA Primers--chemistry DNA-Binding Proteins--physiology Enhancer Elements, Genetic Female Gene Expression Regulation, Enzymologic Hepatocyte Nuclear Factor 4 Liver--enzymology Male Mice Mice, Transgenic Molecular Sequence Data Nuclear Proteins--physiology Ornithine Carbamoyltransferase--genetics Phosphoproteins Promoter Regions, Genetic Sequence Deletion Structure-Activity Relationship Tissue Distribution Transcription Factors--physiology Transcription, Genetic Transfection