Kam, C M <br/><br/>
Mechanism-based isocoumarin inhibitors for blood coagulation serine proteases. Effect of the 7-substituent in 7-amino-4-chloro-3-(isothioureidoalkoxy)isocoumarins on inhibitory and anticoagulant potency.  [electronic resource] 

 -  Journal of medicinal chemistry  Apr 1994 
 - 1298-306 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. 
<br/><br/><label>ISSN: </label>0022-2623 
<br/><br/><label>Standard No.: </label>10.1021/jm00035a009  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Amino Acid Sequence<br/>Animals<br/>Anticoagulants--chemistry<br/>Binding Sites<br/>Blood Coagulation--drug effects<br/>Cattle<br/>Coumarins--chemistry<br/>Factor IXa--antagonists & inhibitors<br/>Factor VIIIa--pharmacology<br/>Humans<br/>Hydrolysis<br/>Isocoumarins<br/>Liposomes--metabolism<br/>Models, Molecular<br/>Molecular Sequence Data<br/>Molecular Structure<br/>Serine Proteinase Inhibitors--chemistry<br/>Swine<br/>Thrombin--antagonists & inhibitors