TY  - GEN
AU  - Porter,D J
AU  - Harrington,J A
AU  - Almond,M R
AU  - Lowen,G T
AU  - Zimmerman,T P
AU  - Spector,T
TI  - 5-ethynyl-2(1H)-pyrimidinone: aldehyde oxidase-activation to 5-ethynyluracil, a mechanism-based inactivator of dihydropyrimidine dehydrogenase
SN  - 0006-2952
PY  - 1994///0518
KW  - Aldehyde Oxidase
KW  - Aldehyde Oxidoreductases
KW  - antagonists & inhibitors
KW  - Animals
KW  - Biotransformation
KW  - Dihydrouracil Dehydrogenase (NADP)
KW  - Intestines
KW  - drug effects
KW  - Liver
KW  - Lung
KW  - Oxidation-Reduction
KW  - Oxidoreductases
KW  - Prodrugs
KW  - pharmacology
KW  - Pyrimidinones
KW  - chemical synthesis
KW  - Rabbits
KW  - Rats
KW  - Uracil
KW  - analogs & derivatives
KW  - Xanthine Oxidase
KW  - metabolism
N1  - Publication Type: Comparative Study; Journal Article
UR  - https://doi.org/10.1016/0006-2952(94)90388-3
ER  -