An in-frame insertion into the Sindbis virus 6K gene leads to defective proteolytic processing of the virus glycoproteins, a trans-dominant negative inhibition of normal virus formation, and interference in virus shut off of host-cell protein synthesis. [electronic resource]
- Virology Mar 1993
- 424-32 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
0042-6822
10.1006/viro.1993.1139 doi
Amino Acid Sequence Animals Cells, Cultured Chick Embryo Cricetinae Culicidae Genes, Viral--genetics Glycoproteins--genetics Molecular Sequence Data Mutagenesis, Insertional Protein Biosynthesis Protein Processing, Post-Translational--genetics Sindbis Virus--genetics Viral Proteins--genetics Virion--chemistry