Adolescent Adrenal Cortex Hormones--therapeutic use Adult Combined Modality Therapy Cyclophosphamide--therapeutic use Drug Evaluation Drug Therapy, Combination Female Humans Interferon Type I--therapeutic use Interferon alpha-2 Interferon-alpha Interferon-gamma--therapeutic use Lupus Erythematosus, Systemic--therapy Male Middle Aged Recombinant Proteins Time Factors