Ibutilide, a methanesulfonanilide antiarrhythmic, is a potent blocker of the rapidly activating delayed rectifier K+ current (IKr) in AT-1 cells. Concentration-, time-, voltage-, and use-dependent effects. [electronic resource]
- Circulation Mar 1995
- 1799-806 p. digital
Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
0009-7322
10.1161/01.cir.91.6.1799 doi
Animals Anti-Arrhythmia Agents--pharmacology Cell Line Cells, Cultured Dose-Response Relationship, Drug Heart--drug effects Mice Patch-Clamp Techniques Phenethylamines--pharmacology Potassium Channel Blockers Sulfonamides--pharmacology Time Factors