McDonald, B J

Effect of dexamethasone treatment on the biotransformation of glyceryl trinitrate: cytochrome P450 3A1 mediated activation of rat aortic guanylyl cyclase by glyceryl trinitrate. [electronic resource] - Canadian journal of physiology and pharmacology Dec 1994 - 1513-20 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

0008-4212

10.1139/y94-217 doi


Animals
Aorta--drug effects
Aryl Hydrocarbon Hydroxylases
Biotransformation
Cytochrome P-450 CYP3A
Cytochrome P-450 Enzyme System--drug effects
Dexamethasone--pharmacology
Enzyme Activation
Female
Guanylate Cyclase--drug effects
In Vitro Techniques
Male
Microsomes, Liver--drug effects
Mixed Function Oxygenases--drug effects
Nitroglycerin--metabolism
Rats
Rats, Sprague-Dawley
Vasoconstriction--drug effects