TY - GEN AU - Ruff-Jamison,S AU - Glenney,J R TI - Molecular modeling and site-directed mutagenesis of an anti-phosphotyrosine antibody predicts the combining site and allows the detection of higher affinity interactions SN - 0269-2139 PY - 1993///1208 KW - Amino Acid Sequence KW - Antibodies, Monoclonal KW - chemistry KW - Antigen-Antibody Reactions KW - Binding Sites, Antibody KW - Blotting, Western KW - Computer Simulation KW - Crystallography, X-Ray KW - Enzyme-Linked Immunosorbent Assay KW - Immunoglobulin Fab Fragments KW - Immunoglobulin Heavy Chains KW - Immunoglobulin Light Chains KW - Immunoglobulin Variable Region KW - Models, Molecular KW - Molecular Sequence Data KW - Mutagenesis, Site-Directed KW - Phosphotyrosine KW - Polymerase Chain Reaction KW - Protein Conformation KW - Sequence Alignment KW - Sequence Homology, Amino Acid KW - Templates, Genetic KW - Tyrosine KW - analogs & derivatives N1 - Publication Type: Comparative Study; Journal Article UR - https://doi.org/10.1093/protein/6.6.661 ER -