Ruff-Jamison, S <br/><br/>
Molecular modeling and site-directed mutagenesis of an anti-phosphotyrosine antibody predicts the combining site and allows the detection of higher affinity interactions.  [electronic resource] 

 -  Protein engineering  Aug 1993 
 - 661-8 p.  digital 
<br/><br/> Publication Type: Comparative Study; Journal Article 
<br/><br/><label>ISSN: </label>0269-2139 
<br/><br/><label>Standard No.: </label>10.1093/protein/6.6.661  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Amino Acid Sequence<br/>Antibodies, Monoclonal--chemistry<br/>Antigen-Antibody Reactions<br/>Binding Sites, Antibody<br/>Blotting, Western<br/>Computer Simulation<br/>Crystallography, X-Ray<br/>Enzyme-Linked Immunosorbent Assay<br/>Immunoglobulin Fab Fragments--chemistry<br/>Immunoglobulin Heavy Chains--chemistry<br/>Immunoglobulin Light Chains--chemistry<br/>Immunoglobulin Variable Region--chemistry<br/>Models, Molecular<br/>Molecular Sequence Data<br/>Mutagenesis, Site-Directed<br/>Phosphotyrosine<br/>Polymerase Chain Reaction<br/>Protein Conformation<br/>Sequence Alignment<br/>Sequence Homology, Amino Acid<br/>Templates, Genetic<br/>Tyrosine--analogs & derivatives