BCR/ABL oncoprotein-targeted antitumor activity of antisense oligodeoxynucleotides complementary to bcr/abl mRNA and herbimycin A, an antagonist of protein tyrosine kinase: inhibitory effects on in vitro growth of Ph1-positive leukemia cells and BCR/ABL oncoprotein-associated transformed cells. [electronic resource]
- Leukemia & lymphoma Jul 1993
- 307-16 p. digital
Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
1042-8194
10.3109/10428199309148553 doi
Antibiotics, Antineoplastic--pharmacology Base Sequence Benzoquinones Cell Division--drug effects DNA, Antisense--therapeutic use Dose-Response Relationship, Drug Fusion Proteins, bcr-abl--antagonists & inhibitors Humans Lactams, Macrocyclic Leukemia, Myelogenous, Chronic, BCR-ABL Positive--drug therapy Molecular Sequence Data Neoplasm Proteins--antagonists & inhibitors Philadelphia Chromosome Polymerase Chain Reaction Precursor Cell Lymphoblastic Leukemia-Lymphoma--drug therapy Protein-Tyrosine Kinases--antagonists & inhibitors Quinones--pharmacology RNA-Directed DNA Polymerase Rifabutin--analogs & derivatives Tumor Cells, Cultured--drug effects