Identification of mutations in the coding sequence of the proto-oncogene c-kit in a human mast cell leukemia cell line causing ligand-independent activation of c-kit product. [electronic resource]
- The Journal of clinical investigation Oct 1993
- 1736-44 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
0021-9738
10.1172/JCI116761 doi
Amino Acid Sequence Animals Base Sequence Cell Line DNA Primers Granulocyte-Macrophage Colony-Stimulating Factor--pharmacology Humans Interleukin-3--pharmacology Leukemia, Mast-Cell--genetics Mice Molecular Sequence Data Phosphotyrosine Point Mutation Polymerase Chain Reaction Proto-Oncogene Mas Proto-Oncogene Proteins--biosynthesis Proto-Oncogene Proteins c-kit Proto-Oncogenes Receptor Protein-Tyrosine Kinases--biosynthesis Receptors, Colony-Stimulating Factor--biosynthesis Recombinant Proteins--pharmacology Transfection Tumor Cells, Cultured Tyrosine--analogs & derivatives