TY  - GEN
AU  - Lu,K
AU  - Yin,M B
AU  - McGuire,J J
AU  - Bonmassar,E
AU  - Rustum,Y M
TI  - Mechanisms of resistance to N-[5-[N-(3,4-dihydro-2-methyl-4- oxoquinazolin-6-ylmethyl)-N-methylamino]-2-thenoyl]-L-glutamic acid (ZD1694), a folate-based thymidylate synthase inhibitor, in the HCT-8 human ileocecal adenocarcinoma cell line
SN  - 0006-2952
PY  - 1995///0919
KW  - Cell Division
KW  - drug effects
KW  - Cell-Free System
KW  - Dose-Response Relationship, Drug
KW  - Drug Resistance
KW  - Folic Acid Antagonists
KW  - pharmacology
KW  - Glutamates
KW  - Guanine
KW  - analogs & derivatives
KW  - Humans
KW  - Methotrexate
KW  - Pemetrexed
KW  - Peptide Synthases
KW  - antagonists & inhibitors
KW  - Pteroylpolyglutamic Acids
KW  - metabolism
KW  - Quinazolines
KW  - Thiophenes
KW  - Thymidylate Synthase
KW  - Time Factors
KW  - Tumor Cells, Cultured
N1  - Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S
UR  - https://doi.org/10.1016/0006-2952(95)00135-m
ER  -