Lu, K <br/><br/>
Mechanisms of resistance to N-[5-[N-(3,4-dihydro-2-methyl-4- oxoquinazolin-6-ylmethyl)-N-methylamino]-2-thenoyl]-L-glutamic acid (ZD1694), a folate-based thymidylate synthase inhibitor, in the HCT-8 human ileocecal adenocarcinoma cell line.  [electronic resource] 

 -  Biochemical pharmacology  Jul 1995 
 - 391-8 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S. 
<br/><br/><label>ISSN: </label>0006-2952 
<br/><br/><label>Standard No.: </label>10.1016/0006-2952(95)00135-m  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Cell Division--drug effects<br/>Cell-Free System<br/>Dose-Response Relationship, Drug<br/>Drug Resistance<br/>Folic Acid Antagonists--pharmacology<br/>Glutamates--pharmacology<br/>Guanine--analogs & derivatives<br/>Humans<br/>Methotrexate--pharmacology<br/>Pemetrexed<br/>Peptide Synthases--antagonists & inhibitors<br/>Pteroylpolyglutamic Acids--metabolism<br/>Quinazolines--pharmacology<br/>Thiophenes--pharmacology<br/>Thymidylate Synthase--antagonists & inhibitors<br/>Time Factors<br/>Tumor Cells, Cultured--drug effects