TY - GEN AU - Collins,D M AU - Kawakami,R P AU - de Lisle,G W AU - Pascopella,L AU - Bloom,B R AU - Jacobs,W R TI - Mutation of the principal sigma factor causes loss of virulence in a strain of the Mycobacterium tuberculosis complex SN - 0027-8424 PY - 1995///0921 KW - Amino Acid Sequence KW - Animals KW - Base Sequence KW - Cloning, Molecular KW - Cosmids KW - Genes, Bacterial KW - Genetic Complementation Test KW - Guinea Pigs KW - Molecular Sequence Data KW - Mycobacterium KW - genetics KW - Mycobacterium bovis KW - Mycobacterium tuberculosis KW - Open Reading Frames KW - Recombination, Genetic KW - Sequence Deletion KW - Sequence Homology, Nucleic Acid KW - Sigma Factor KW - Spleen KW - microbiology KW - Streptomyces griseus KW - Tuberculosis KW - physiopathology KW - Virulence KW - physiology N1 - Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S UR - https://doi.org/10.1073/pnas.92.17.8036 ER -