TY  - GEN
AU  - Jonckheere,H
AU  - Taymans,J M
AU  - Balzarini,J
AU  - Velázquez,S
AU  - Camarasa,M J
AU  - Desmyter,J
AU  - De Clercq,E
AU  - Anné,J
TI  - Resistance of HIV-1 reverse transcriptase against [2',5'-bis-O-(tert-butyldimethylsilyl)-3'-spiro-5''-(4''-amino-1'',2''- oxathiole-2'',2''-dioxide)] (TSAO) derivatives is determined by the mutation Glu138-->Lys on the p51 subunit
SN  - 0021-9258
PY  - 1994///1117
KW  - Antiviral Agents
KW  - chemistry
KW  - Base Sequence
KW  - Benzodiazepines
KW  - pharmacology
KW  - Binding Sites
KW  - genetics
KW  - Deoxyguanine Nucleotides
KW  - Dideoxynucleotides
KW  - Drug Resistance
KW  - Escherichia coli
KW  - HIV Reverse Transcriptase
KW  - Imidazoles
KW  - Molecular Sequence Data
KW  - Mutagenesis, Site-Directed
KW  - Mutation
KW  - Protein Conformation
KW  - RNA-Directed DNA Polymerase
KW  - Recombinant Proteins
KW  - metabolism
KW  - Reverse Transcriptase Inhibitors
KW  - Sequence Analysis, DNA
KW  - Spiro Compounds
KW  - Thymidine
KW  - analogs & derivatives
KW  - Uridine
N1  - Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
ER  -