Jonckheere, H <br/><br/>
Resistance of HIV-1 reverse transcriptase against [2',5'-bis-O-(tert-butyldimethylsilyl)-3'-spiro-5''-(4''-amino-1'',2''- oxathiole-2'',2''-dioxide)] (TSAO) derivatives is determined by the mutation Glu138-->Lys on the p51 subunit.  [electronic resource] 

 -  The Journal of biological chemistry  Oct 1994 
 - 25255-8 p.  digital 
<br/><br/> Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>0021-9258 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Antiviral Agents--chemistry<br/>Base Sequence<br/>Benzodiazepines--pharmacology<br/>Binding Sites--genetics<br/>Deoxyguanine Nucleotides--pharmacology<br/>Dideoxynucleotides<br/>Drug Resistance--genetics<br/>Escherichia coli--genetics<br/>HIV Reverse Transcriptase<br/>Imidazoles--pharmacology<br/>Molecular Sequence Data<br/>Mutagenesis, Site-Directed<br/>Mutation<br/>Protein Conformation<br/>RNA-Directed DNA Polymerase--genetics<br/>Recombinant Proteins--metabolism<br/>Reverse Transcriptase Inhibitors<br/>Sequence Analysis, DNA<br/>Spiro Compounds<br/>Thymidine--analogs & derivatives<br/>Uridine--analogs & derivatives