Baccanari, D P Effect of a single amino acid substitution on Escherichia coli dihydrofolate reductase catalysis and ligand binding. [electronic resource] - The Journal of biological chemistry Feb 1981 - 1738-47 p. digital Publication Type: Comparative Study; Journal Article ISSN: 0021-9258 Subjects--Topical Terms: Amino Acid SequenceAmino Acids--analysisDrug Resistance, MicrobialEscherichia coli--drug effectsIsoenzymes--metabolismKineticsLigandsProtein BindingTetrahydrofolate Dehydrogenase--metabolismTrimethoprim--pharmacology