Synthesis and evaluation of novel N-substituted N'-(3-hydroxy-17-oxoestra-1,3,5(10)-trien-2- and -4-yl)thiourea derivatives for binding to the estrogen receptor and cytotoxic activity on MCF-7 cells. [electronic resource]
- Journal of pharmaceutical sciences Dec 1984
- 1871-3 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
0022-3549
10.1002/jps.2600731263 doi
Animals Antineoplastic Agents--chemical synthesis Breast Neoplasms--pathology Cell Division--drug effects Cell Line Chemical Phenomena Chemistry Estrenes--chemical synthesis Estrogen Antagonists--chemical synthesis Female Humans In Vitro Techniques Rats Receptors, Estrogen--metabolism Thiourea--analogs & derivatives Uterus--metabolism