TY  - GEN
AU  - Villafranca,J E
AU  - Howell,E E
AU  - Voet,D H
AU  - Strobel,M S
AU  - Ogden,R C
AU  - Abelson,J N
AU  - Kraut,J
TI  - Directed mutagenesis of dihydrofolate reductase
SN  - 0036-8075
PY  - 1983///1217
KW  - Amino Acid Sequence
KW  - Base Sequence
KW  - Disulfides
KW  - Escherichia coli
KW  - genetics
KW  - Gene Expression Regulation
KW  - Genes
KW  - Genes, Bacterial
KW  - Mutation
KW  - Structure-Activity Relationship
KW  - Tetrahydrofolate Dehydrogenase
N1  - Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S
UR  - https://doi.org/10.1126/science.6356360
ER  -