TY  - GEN
AU  - Calvert,A H
AU  - Alison,D L
AU  - Harland,S J
AU  - Robinson,B A
AU  - Jackman,A L
AU  - Jones,T R
AU  - Newell,D R
AU  - Siddik,Z H
AU  - Wiltshaw,E
AU  - McElwain,T J
TI  - A phase I evaluation of the quinazoline antifolate thymidylate synthase inhibitor, N10-propargyl-5,8-dideazafolic acid, CB3717
SN  - 0732-183X
PY  - 1986///0917
KW  - Acetylglucosaminidase
KW  - urine
KW  - Acid Phosphatase
KW  - blood
KW  - Alanine Transaminase
KW  - Antineoplastic Agents
KW  - administration & dosage
KW  - Chemical and Drug Induced Liver Injury
KW  - Dose-Response Relationship, Drug
KW  - Drug Administration Schedule
KW  - Drug Evaluation
KW  - Folic Acid
KW  - analogs & derivatives
KW  - Folic Acid Antagonists
KW  - Glomerular Filtration Rate
KW  - drug effects
KW  - Hematologic Diseases
KW  - chemically induced
KW  - Hyperbilirubinemia
KW  - Kidney Diseases
KW  - Leucyl Aminopeptidase
KW  - Neoplasms
KW  - Quinazolines
KW  - Skin Diseases
KW  - Thymidylate Synthase
KW  - antagonists & inhibitors
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1200/JCO.1986.4.8.1245
ER  -