Lettéron, P Methoxsalen decreases the metabolic activation and prevents the hepatotoxicity and nephrotoxicity of chloroform in mice. [electronic resource] - Toxicology and applied pharmacology Nov 1987 - 266-73 p. digital Publication Type: Journal Article ISSN: 0041-008X Standard No.: 10.1016/0041-008x(87)90107-4 doi Subjects--Topical Terms: 7-Alkoxycoumarin O-DealkylaseAminopyrine N-Demethylase--metabolismAnimalsBiotransformationChloroform--metabolismCytochrome P-450 Enzyme System--metabolismDose-Response Relationship, DrugKidney--drug effectsLiver--drug effectsMaleMethoxsalen--pharmacologyMiceMice, Inbred StrainsMicrosomes--enzymologyMicrosomes, Liver--enzymologyNADPH-Ferrihemoprotein Reductase--metabolismOxygenases--metabolismProteins--metabolism