TY  - GEN
AU  - Steeneck,Christoph
AU  - Gege,Christian
AU  - Kinzel,Olaf
AU  - Albers,Michael
AU  - Kleymann,Gerald
AU  - Schlüter,Thomas
AU  - Schulz,Andreas
AU  - Xue,Xiaohua
AU  - Cummings,Maxwell D
AU  - Fourie,Anne M
AU  - Leonard,Kristi A
AU  - Scott,Brian
AU  - Edwards,James P
AU  - Hoffmann,Thomas
AU  - Goldberg,Steven D
TI  - Discovery and optimization of new oxadiazole substituted thiazole RORγt inverse agonists through a bioisosteric amide replacement approach
SN  - 1464-3405
PY  - 2021///0512
KW  - Administration, Oral
KW  - Amides
KW  - administration & dosage
KW  - Animals
KW  - Dose-Response Relationship, Drug
KW  - Drug Discovery
KW  - Microsomes, Liver
KW  - chemistry
KW  - Molecular Structure
KW  - Nuclear Receptor Subfamily 1, Group F, Member 3
KW  - agonists
KW  - Oxadiazoles
KW  - Rats
KW  - Structure-Activity Relationship
KW  - Thiazoles
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1016/j.bmcl.2020.127174
ER  -