Novel AXL-specific inhibitor ameliorates kidney dysfunction through the inhibition of epithelial-to-mesenchymal transition of renal tubular cells. [electronic resource]
- PloS one 2020
- e0232055 p. digital
Publication Type: Journal Article
1932-6203
10.1371/journal.pone.0232055 doi
Albumins--analysis Animals Cell Line Creatinine--blood Disease Models, Animal Dose-Response Relationship, Drug Epithelial-Mesenchymal Transition--drug effects Gene Expression Regulation--drug effects Glomerulonephritis--drug therapy Heterocyclic Compounds, 4 or More Rings--administration & dosage Humans Intercellular Signaling Peptides and Proteins--genetics Kidney--drug effects Kidney Function Tests Kidney Tubules--cytology Mice Mice, Transgenic Molecular Structure Protein Kinase Inhibitors--administration & dosage Proto-Oncogene Proteins--antagonists & inhibitors Rats Receptor Protein-Tyrosine Kinases--antagonists & inhibitors Transforming Growth Factor beta1--genetics Axl Receptor Tyrosine Kinase