Structural and kinetic evidence of aging after organophosphate inhibition of human Cathepsin A. [electronic resource]
- Biochemical pharmacology 07 2020
- 113980 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
1873-2968
10.1016/j.bcp.2020.113980 doi
Acetylcholinesterase--chemistry Binding Sites Cathepsin A--antagonists & inhibitors Cell Line Chemical Warfare Agents--chemistry Cholinesterase Inhibitors--chemistry Crystallography, X-Ray GPI-Linked Proteins--antagonists & inhibitors Gene Expression HEK293 Cells Humans Isoflurophate--chemistry Kinetics Models, Molecular Organophosphorus Compounds--chemistry Organothiophosphorus Compounds--chemistry Protein Binding Protein Conformation, alpha-Helical Protein Conformation, beta-Strand Protein Interaction Domains and Motifs Recombinant Proteins--chemistry Sarin--chemistry Soman--chemistry Substrate Specificity Time Factors