TY  - GEN
AU  - Sbardella,Diego
AU  - Coletta,Andrea
AU  - Tundo,Grazia Raffaella
AU  - Ahmed,Ikhlas M M
AU  - Bellia,Francesco
AU  - Oddone,Francesco
AU  - Manni,Gianluca
AU  - Coletta,Massimo
TI  - Structural and functional evidence for citicoline binding and modulation of 20S proteasome activity: Novel insights into its pro-proteostatic effect
SN  - 1873-2968
PY  - 2020///1201
KW  - Allosteric Regulation
KW  - Amino Acid Sequence
KW  - Binding Sites
KW  - Cell Line, Tumor
KW  - Cytidine Diphosphate Choline
KW  - chemistry
KW  - Gene Expression
KW  - Humans
KW  - Kinetics
KW  - Molecular Docking Simulation
KW  - Neurons
KW  - drug effects
KW  - Neuroprotective Agents
KW  - Nootropic Agents
KW  - Proteasome Endopeptidase Complex
KW  - Proteasome Inhibitors
KW  - Protein Binding
KW  - Protein Conformation, alpha-Helical
KW  - Protein Conformation, beta-Strand
KW  - Protein Interaction Domains and Motifs
KW  - Proteostasis
KW  - Recombinant Proteins
KW  - Sequence Alignment
KW  - Sequence Homology, Amino Acid
KW  - Substrate Specificity
KW  - Thermodynamics
KW  - alpha-Synuclein
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1016/j.bcp.2020.113977
ER  -