VHL-HIF-2α axis-induced SMYD3 upregulation drives renal cell carcinoma progression via direct trans-activation of EGFR. [electronic resource]
- Oncogene 05 2020
- 4286-4298 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1476-5594
10.1038/s41388-020-1291-7 doi
Animals Basic Helix-Loop-Helix Transcription Factors--genetics Carcinoma, Renal Cell--genetics ErbB Receptors--biosynthesis Gene Expression Regulation, Neoplastic Histone-Lysine N-Methyltransferase--biosynthesis Humans Kidney Neoplasms--genetics Male Mice Mice, Inbred BALB C Mice, Nude Neoplasm Proteins--genetics Signal Transduction Transcriptional Activation Up-Regulation Von Hippel-Lindau Tumor Suppressor Protein--genetics