TY  - GEN
AU  - Sarkar,Saswata S
AU  - Trivedi,Darshan V
AU  - Morck,Makenna M
AU  - Adhikari,Arjun S
AU  - Pasha,Shaik N
AU  - Ruppel,Kathleen M
AU  - Spudich,James A
TI  - The hypertrophic cardiomyopathy mutations R403Q and R663H increase the number of myosin heads available to interact with actin
SN  - 2375-2548
PY  - 2020///1214
KW  - Actins
KW  - chemistry
KW  - Alleles
KW  - Amino Acid Substitution
KW  - Binding Sites
KW  - Cardiomyopathy, Hypertrophic
KW  - genetics
KW  - Genetic Predisposition to Disease
KW  - Humans
KW  - Models, Molecular
KW  - Mutation
KW  - Myocardial Contraction
KW  - Myosins
KW  - Protein Binding
KW  - Protein Conformation
KW  - Structure-Activity Relationship
KW  - Ventricular Myosins
N1  - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1126/sciadv.aax0069
ER  -