Sarkar, Saswata S <br/><br/>
The hypertrophic cardiomyopathy mutations R403Q and R663H increase the number of myosin heads available to interact with actin.  [electronic resource] 

 -  Science advances  04 2020 
 - eaax0069 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>2375-2548 
<br/><br/><label>Standard No.: </label>10.1126/sciadv.aax0069  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Actins--chemistry<br/>Alleles<br/>Amino Acid Substitution<br/>Binding Sites<br/>Cardiomyopathy, Hypertrophic--genetics<br/>Genetic Predisposition to Disease<br/>Humans<br/>Models, Molecular<br/>Mutation<br/>Myocardial Contraction--genetics<br/>Myosins--chemistry<br/>Protein Binding<br/>Protein Conformation<br/>Structure-Activity Relationship<br/>Ventricular Myosins--genetics