TY - GEN AU - Mathony,Jan AU - Harteveld,Zander AU - Schmelas,Carolin AU - Upmeier Zu Belzen,Julius AU - Aschenbrenner,Sabine AU - Sun,Wei AU - Hoffmann,Mareike D AU - Stengl,Christina AU - Scheck,Andreas AU - Georgeon,Sandrine AU - Rosset,Stéphane AU - Wang,Yanli AU - Grimm,Dirk AU - Eils,Roland AU - Correia,Bruno E AU - Niopek,Dominik TI - Computational design of anti-CRISPR proteins with improved inhibition potency SN - 1552-4469 PY - 2020///1008 KW - Amino Acid Sequence KW - CRISPR-Associated Protein 9 KW - genetics KW - CRISPR-Cas Systems KW - Cell Line, Tumor KW - Clustered Regularly Interspaced Short Palindromic Repeats KW - Gene Editing KW - methods KW - Genome, Human KW - HEK293 Cells KW - Hepatocytes KW - cytology KW - Humans KW - MicroRNAs KW - Models, Molecular KW - Mutagenesis, Insertional KW - Neisseria meningitidis KW - enzymology KW - Plasmids KW - chemistry KW - Protein Domains KW - Protein Engineering KW - Protein Structure, Secondary KW - RNA, Guide, CRISPR-Cas Systems KW - Staphylococcus aureus N1 - Publication Type: Journal Article; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1038/s41589-020-0518-9 ER -