TY  - GEN
AU  - Huang,Wan-Yun
AU  - Zhang,Xiao-Rong
AU  - Lyu,Liang
AU  - Wang,Shu-Qin
AU  - Zhang,Xiao-Ting
TI  - Pyridazino[1,6-b]quinazolinones as new anticancer scaffold: Synthesis, DNA intercalation, topoisomerase I inhibition and antitumor evaluation in vitro and in vivo
SN  - 1090-2120
PY  - 2021///0302
KW  - Animals
KW  - Antineoplastic Agents
KW  - chemical synthesis
KW  - Apoptosis
KW  - drug effects
KW  - Cattle
KW  - Cell Cycle
KW  - Cell Proliferation
KW  - DNA
KW  - chemistry
KW  - DNA Topoisomerases, Type I
KW  - metabolism
KW  - Dose-Response Relationship, Drug
KW  - Drug Screening Assays, Antitumor
KW  - Humans
KW  - Molecular Docking Simulation
KW  - Molecular Structure
KW  - Quinazolinones
KW  - Structure-Activity Relationship
KW  - Topoisomerase I Inhibitors
KW  - Tumor Cells, Cultured
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1016/j.bioorg.2020.103814
ER  -