Huang, Wan-Yun <br/><br/>
Pyridazino[1,6-b]quinazolinones as new anticancer scaffold: Synthesis, DNA intercalation, topoisomerase I inhibition and antitumor evaluation in vitro and in vivo.  [electronic resource] 

 -  Bioorganic chemistry  06 2020 
 - 103814 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>1090-2120 
<br/><br/><label>Standard No.: </label>10.1016/j.bioorg.2020.103814  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Animals<br/>Antineoplastic Agents--chemical synthesis<br/>Apoptosis--drug effects<br/>Cattle<br/>Cell Cycle--drug effects<br/>Cell Proliferation--drug effects<br/>DNA--chemistry<br/>DNA Topoisomerases, Type I--metabolism<br/>Dose-Response Relationship, Drug<br/>Drug Screening Assays, Antitumor<br/>Humans<br/>Molecular Docking Simulation<br/>Molecular Structure<br/>Quinazolinones--chemical synthesis<br/>Structure-Activity Relationship<br/>Topoisomerase I Inhibitors--chemical synthesis<br/>Tumor Cells, Cultured